Acetic Acid

Acetic Acid

SCHEMBL2186272

CC#N.CC(=O)[O-].O.O.O.[Na+]

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.64
CA4 P22748 4/20 0.47
FAHD1 Q6P587 1/20 0.38
CA2 P00918 3/20 0.33
LMNA P02545 1/20 0.33
FFAR3 O14843 2/20 0.32
HDAC3 O15379 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC2 Q92769 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
MEN1 O00255 1/20 0.32
LDHA P00338 1/20 0.32
BLM P54132 1/20 0.32
KMT2A Q03164 1/20 0.32
TSHR P16473 1/20 0.31
THPO P40225 1/20 0.31
LCK P06239 1/20 0.31
FYN P06241 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL3173468 1.00
Acetic Acid SCHEMBL8206910 1.00
Acetic Acid SCHEMBL27972026 0.97 CA1 (0.60) CA1CA4FAHD1CA2LMNA
Acetic Acid SCHEMBL10534378 0.97 CA1 (0.60) CA1CA4FAHD1CA2LMNA
Acetic Acid SCHEMBL28015778 0.94 CA1 (0.56) CA1CA4FAHD1CA2FFAR3
Acetic Acid SCHEMBL29046887 0.93 CA1 (0.57) CA1CA4LMNAFFAR3TDP1
Acetic Acid SCHEMBL28420347 0.93 CA1 (0.57) CA1CA4LMNAFFAR3TDP1
Acetic Acid SCHEMBL27897081 0.93 CA1 (0.57) CA1CA4LMNAFFAR3TDP1
Acetic Acid SCHEMBL17747086 0.93 CA1 (0.57) CA1CA4LMNAFFAR3TDP1
Acetic Acid SCHEMBL28318641 0.93 CA1 (0.57) CA1CA4LMNAFFAR3TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114081185-A Gamma-aminobutyric acid detection method and composition for improving sleep and resisting anxiety 程新 2022-02-25 CN disclosed
CN-110596293-B High performance liquid detection method for homopiperazine 山东威高药业股份有限公司 2021-07-20 CN disclosed
CN-110596293-A High performance liquid detection method for homopiperazine 山东威高药业股份有限公司 2019-12-20 CN disclosed
EP-1654283-B1 IMPROVED METHOD OF PURIFYING TFPI AND TFPI ANALOGS NOVARTIS VACCINES & DIAGNOSTIC (US) 2011-07-13 EP disclosed
US-7851433-B2 Method of purifying TFPI and TFPI analogs NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2010-12-14 US disclosed
US-20080281084-A1 Formulation, Solubilization, Purification, and Refolding of Tissue Factor Pathway Inhibitor NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2008-11-13 US disclosed
EP-1589949-B1 STABILIZED LYOPHILIZED COMPOSITIONS COMPRISING TISSUE FACTOR PATHWAY INHIBITOR OR TISSUE FACTOR PATHWAY INHIBITOR VARIANTS NOVARTIS VACCINES & DIAGNOSTIC (US) 2008-08-13 EP disclosed
EP-1803445-A2 Stabilized lyophilized compositions comprising tissue factor pathway inhibitor or tissue factor pathway inhibitor variants Novartis Vaccines and Diagnostics, Inc. (US) 2007-07-04 EP disclosed
US-7226757-B2 Formulation, solubilization, purification, and refolding of tissue factor pathway inhibitor G.D. SEARLE LLC (US) 2007-06-05 US disclosed
EP-1602667-B1 Aqueous formulation comprising TFPI and solubilizing agents NOVARTIS VACCINES & DIAGNOSTIC (US) 2007-04-04 EP disclosed
WO-2005019265-A1 IMPROVED METHOD OF PURIFYING TFPI AND TFPI ANALOGS CHIRON CORPORATION (US) 2005-03-03 WO disclosed
US-20050037475-A1 Method of purifying TFPI and TFPI analogs CHIRON CORPORATION (US) 2005-02-17 US disclosed
US-20040180827-A1 Stabilized lyophilized compositions comprising tissue factor pathway inhibitor or tissue factor pathway inhibitor variants CHIRON CORPORATION (US) 2004-09-16 US disclosed
WO-2004062646-A1 STABILIZED LYOPHILIZED COMPOSITIONS COMPRISING TISSUE FACTOR PATHWAY INHIBITOR OR TISSUE FACTOR PATHWAY INHIBITOR VARIANTS CHIRON CORPORATION (US) 2004-07-29 WO disclosed
US-20020137884-A1 Formulation, solubilization, purification, and refolding of tissue factor pathway inhibitor CHIRON CORPORATION 2002-09-26 US disclosed
US-6323326-B1 MIXTURE OF TISSUE FACTOR PATHWAY IHIBITOR; FOR USE IN PREVENTION OF THROMBOSIS DURING VASCULAR SUSTEM SURGERY; FOR PREVENTION OF SEPSIS CHIRON CORPORATION 2001-11-27 US disclosed
US-6319896-B1 ADDING AQUEOUS SOLUTION OF CHARGED POLYMER TO SOLUTION OF PURIFIED PROTEIN TO REDUCE INTERMOLECULAR OR INTRAMOLECULAR INTERACTIONS BETWEEN THE POSITIVELY AND NEGATIVELY CHARGED DOMAINS WHEREBY SOLUBILITY OF PROTEIN IS INCREASED CHIRON CORPORATION 2001-11-20 US disclosed
US-5888968-A TFPI formulation CHIRON CORPORATION (US) 1999-03-30 US disclosed
EP-0837883-A2 METHOD OF SOLUBILIZING, PURIFYING, AND REFOLDING PROTEIN CHIRON CORPORATION (US) 1998-04-29 EP disclosed
WO-1996040784-A2 METHOD OF SOLUBILIZING, PURIFYING, AND REFOLDING PROTEIN CHIRON CORPORATION (US) 1996-12-19 WO disclosed