Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL29140957 | 0.98 | HTT (0.52) | HTTNPC1PPARAGPR84FFAR1 | |
| Terephthalic Acid SCHEMBL27660838 | 0.95 | HTT (0.54) | HTTNPC1POLBAPEX1TDP1 | |
| Terephthalic Acid SCHEMBL29140943 | 0.94 | HTT (0.56) | HTTPOLBAPEX1TDP1TP53 | |
| Terephthalic Acid SCHEMBL28828870 | 0.94 | HTT (0.56) | HTTPOLBAPEX1TDP1TP53 | |
| Terephthalic Acid SCHEMBL23910546 | 0.94 | HTT (0.55) | HTTNPC1PPARAPOLBAPEX1 | |
| Terephthalic Acid SCHEMBL28361003 | 0.90 | HTT (0.55) | HTTPOLBAPEX1TDP1TP53 | |
| SCHEMBL26795349 | 0.89 | TDP1 (0.53) | HTTNPC1PPARAGPR84FFAR1 | |
| SCHEMBL5852269 | 0.88 | TDP1 (0.54) | HTTNPC1PPARAPOLBAPEX1 | |
| SCHEMBL208716 | 0.87 | GPR84 (0.60) | NPC1PPARAGPR84FFAR1FFAR4 | |
| SCHEMBL19912238 | 0.87 | GPR84 (0.60) | NPC1PPARAGPR84FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130302568-A1 | FILM AND METHOD FOR PRODUCING FILM | FUJIFILM CORP (JP) | 2013-11-14 | — | — | US | disclosed |
| US-8501065-B2 | Film and method for producing film | FUJIFILM CORPORATION (JP) | 2013-08-06 | — | — | US | disclosed |
| EP-1484356-B1 | POLYLACTIC ACID MOLDING AND PROCESS FOR PRODUCING THE SAME | UNITIKA LTD (JP) | 2011-12-28 | — | — | EP | disclosed |
| US-20110177289-A1 | FILM AND METHOD FOR PRODUCING FILM | FUJIFILM CORPORATION (JP) | 2011-07-21 | — | — | US | disclosed |
| EP-2342064-A1 | FILM AND METHOD FOR PRODUCING FILM | FUJIFILM Corporation (JP) | 2011-07-13 | — | — | EP | disclosed |
| US-7854880-B2 | Polylactic acid molding and process for producing the same | UNITIKA LTD. (JP) | 2010-12-21 | — | — | US | disclosed |
| WO-2010038907-A1 | FILM AND METHOD FOR PRODUCING FILM | FUJIFILM CORPORATION (JP) | 2010-04-08 | — | — | WO | disclosed |
| US-20050165142-A1 | Polylactic acid molding and process for producing the same | UNITIKA LTD. (JP) | 2005-07-28 | — | — | US | disclosed |
| EP-1484356-A1 | POLYLACTIC ACID MOLDING AND PROCESS FOR PRODUCING THE SAME | UNITIKA LTD. (JP) | 2004-12-08 | — | — | EP | disclosed |