Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 4/20 | 0.56 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.56 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21864570 | 0.85 | CHEK2 (0.47) | PARP10CHEK2HPGDALDH1A1KDM4E | |
| SCHEMBL21830613 | 0.81 | HPGD (0.37) | PARP10CHEK2HPGDALDH1A1KDM4E | |
| SCHEMBL21864586 | 0.78 | CHEK2 (0.42) | CHEK2HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL21864737 | 0.78 | NOD2 (0.44) | HPGDALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL21864581 | 0.78 | ABL1 (0.45) | CHEK2HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL21864597 | 0.77 | KMT2A (0.44) | HPGDALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL21864571 | 0.76 | IKBKE (0.41) | CHEK2HPGDALDH1A1KDM4EKMT2A | |
| SCHEMBL10138332 | 0.75 | PRKCZ (0.59) | PARP15PARP10PARP2CHEK2 | |
| SCHEMBL21864584 | 0.75 | CA12 (0.39) | HPGDALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL21864601 | 0.75 | CA12 (0.40) | HPGDALDH1A1KDM4ELMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020071550-A1 | CDK8 INHIBITOR AND USE OF SAME | 京都薬品工業株式会社 | 2020-04-09 | — | — | WO | disclosed |