Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 13/20 | 0.41 |
| ▸ | HTR1B | P28222 | 4/20 | 0.41 |
| ▸ | HTR1E | P28566 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21864605 | 0.81 | HTR1D (0.40) | HTR1DHTR1BHTR1EHTR1AGRM2 | |
| SCHEMBL21831364 | 0.80 | CHEK2 (0.40) | CHEK2 | |
| SCHEMBL21864582 | 0.77 | MTNR1B (0.39) | HTR1DHTR1BHTR1ASCN9AXIAP | |
| SCHEMBL21864603 | 0.75 | HTR1D (0.46) | HTR1DHTR1BHTR1EHTR1AGRM2 | |
| SCHEMBL21830577 | 0.71 | MTNR1A (0.42) | — | |
| SCHEMBL21864625 | 0.70 | HTR1D (0.40) | HTR1DHTR1BHTR1EHTR1APDE4D | |
| SCHEMBL21831363 | 0.70 | CHEK2 (0.38) | CHEK2 | |
| SCHEMBL578566 | 0.69 | SLC22A12 (0.41) | CHEK2 | |
| SCHEMBL1318385 | 0.67 | CDK8 (0.42) | CHEK2PDE4DSCN9A | |
| SCHEMBL21864624 | 0.67 | HTR1D (0.38) | HTR1DHTR1BHTR1EHTR1AGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020071550-A1 | CDK8 INHIBITOR AND USE OF SAME | 京都薬品工業株式会社 | 2020-04-09 | — | — | WO | disclosed |