Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 9/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186541 | 0.93 | CHRM4 (0.48) | CHRM4LMNAKMT2AMEN1TSHR | |
| SCHEMBL2186958 | 0.90 | CHRM4 (0.58) | CHRM4CHRM2LMNAKMT2AMEN1 | |
| SCHEMBL2187518 | 0.88 | CHRM4 (0.50) | CHRM4LMNAKMT2AMEN1TSHR | |
| SCHEMBL2188273 | 0.88 | CHRM4 (0.52) | CHRM4LMNAKMT2AMEN1TSHR | |
| SCHEMBL2187381 | 0.88 | STAT3 (0.48) | CHRM4STAT3LMNAKMT2AMEN1 | |
| SCHEMBL2186146 | 0.87 | CHRM4 (0.51) | CHRM4LMNAKMT2AMEN1TSHR | |
| SCHEMBL2188328 | 0.87 | CHRM4 (0.51) | CHRM4LMNAKMT2AMEN1TSHR | |
| SCHEMBL2186627 | 0.87 | LMNA (0.49) | LMNAKMT2AMEN1TSHRMAPK1 | |
| SCHEMBL2186036 | 0.86 | POLB (0.61) | CHRM4LMNAKMT2AMEN1TSHR | |
| SCHEMBL2187544 | 0.86 | CHRM4 (0.50) | CHRM4LMNAKMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |