Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186475 | 0.93 | CHRM4 (0.51) | CHRM4KDM4EALDH1A1KDM4CTDP1 | |
| SCHEMBL2188273 | 0.92 | CHRM4 (0.52) | CHRM4KDM4EALDH1A1KDM4CTDP1 | |
| SCHEMBL2186146 | 0.91 | CHRM4 (0.51) | CHRM4KDM4EALDH1A1KDM4CTDP1 | |
| SCHEMBL2186958 | 0.91 | CHRM4 (0.58) | CHRM4KDM4EALDH1A1KDM4CTDP1 | |
| SCHEMBL2186627 | 0.91 | LMNA (0.49) | KDM4EALDH1A1LMNATSHRHSD17B10 | |
| SCHEMBL2187544 | 0.90 | CHRM4 (0.50) | CHRM4KDM4EALDH1A1KDM4CTDP1 | |
| SCHEMBL2186566 | 0.89 | CHRM4 (0.53) | CHRM4KDM4EALDH1A1KDM4CTDP1 | |
| SCHEMBL2188328 | 0.89 | CHRM4 (0.51) | CHRM4KDM4EALDH1A1KDM4CTDP1 | |
| SCHEMBL2187518 | 0.89 | CHRM4 (0.50) | CHRM4KDM4EALDH1A1KDM4CTDP1 | |
| SCHEMBL2187468 | 0.88 | CHRM4 (0.48) | CHRM4KDM4EALDH1A1KDM4CTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |