⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21223038 | 0.76 | — | — | |
| SCHEMBL231155 | 0.71 | TRPV4 (0.52) | — | |
| SCHEMBL29751851 | 0.67 | — | — | |
| SCHEMBL4316048 | 0.67 | KDM4E (0.43) | — | |
| SCHEMBL114154 | 0.67 | — | — | |
| SCHEMBL137718 | 0.66 | — | — | |
| SCHEMBL29362784 | 0.66 | — | — | |
| SCHEMBL26104326 | 0.66 | CYP2A6 (0.64) | — | |
| SCHEMBL415945 | 0.66 | — | — | |
| Hydrochloric Acid SCHEMBL3168096 | 0.64 | CA1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2455374-B1 | Process for the Preparation of Compounds useful as inhibitors of SGLT | JANSSEN PHARMACEUTICA NV (BE) | 2020-12-16 | — | — | EP | disclosed |
| EP-2994469-B1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES INC (US) | 2018-12-19 | — | — | EP | disclosed |
| US-20180282316-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. | 2018-10-04 | — | — | US | disclosed |
| US-10017501-B2 | Benzimidazole derivatives as bromodomain inhibitors | GILEAD SCIENCES, INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20160376261-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. | 2016-12-29 | — | — | US | disclosed |
| EP-2457908-B1 | Process for the Preparation of Compounds useful as inhibitors of SGLT | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-23 | — | — | EP | disclosed |
| US-9458145-B2 | Benzimidazole derivatives as bromodomain inhibitors | GILEAD SCIENCES, INC. (US) | 2016-10-04 | — | — | US | disclosed |
| US-20160075695-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. (US) | 2016-03-17 | — | — | US | disclosed |
| EP-2994469-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | Gilead Sciences, Inc. (US) | 2016-03-16 | — | — | EP | disclosed |
| US-9056850-B2 | Process for the preparation of compounds useful as inhibitors of SGLT | JANSSEN PHARMACEUTICA N.V. (BE) | 2015-06-16 | — | — | US | disclosed |
| US-20140336190-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. (US) | 2014-11-13 | — | — | US | disclosed |
| WO-2014182929-A1 | BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. (US) | 2014-11-13 | — | — | WO | disclosed |
| EP-2346888-B1 | PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT | JANSSEN PHARMACEUTICA NV (BE) | 2013-01-02 | — | — | EP | disclosed |
| EP-2457908-A1 | Process for the Preparation of Compounds useful as inhibitors of SGLT | Janssen Pharmaceutica N.V. (BE) | 2012-05-30 | — | — | EP | disclosed |
| EP-2455374-A1 | Process for the Preparation of Compounds useful as inhibitors of SGLT | Janssen Pharmaceutica N.V. (BE) | 2012-05-23 | — | — | EP | disclosed |
| EP-2346888-A2 | PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT | Janssen Pharmaceutica, N.V. (BE) | 2011-07-27 | — | — | EP | disclosed |
| US-20100099883-A1 | PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-22 | — | — | US | disclosed |
| WO-2010043682-A2 | PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-22 | — | — | WO | disclosed |