Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | USP8 | P40818 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21886455 | 0.91 | ACHE (0.37) | ACHEBCHEHRH3SIGMAR1 | |
| SCHEMBL21801353 | 0.89 | MAOB (0.37) | ACHEBCHEMAOBPARP1PARP2 | |
| SCHEMBL21801229 | 0.86 | MAOB (0.42) | BCHEMAOBHDAC3HDAC4HDAC1 | |
| SCHEMBL30744121 | 0.86 | MAOB (0.42) | BCHEMAOBHDAC3HDAC4HDAC1 | |
| SCHEMBL21801126 | 0.86 | MAOB (0.42) | BCHEMAOBHDAC3HDAC4HDAC1 | |
| SCHEMBL21801226 | 0.85 | MAOB (0.41) | ACHEBCHEMAOBPARP1PARP2 | |
| SCHEMBL21801185 | 0.84 | MAOB (0.40) | ACHEBCHEMAOBPARP1PARP2 | |
| SCHEMBL21801067 | 0.81 | S1PR1 (0.35) | ACHEBCHEHRH3SIGMAR1 | |
| SCHEMBL21801232 | 0.80 | MAOB (0.44) | BCHEMAOBPARP1PARP2HDAC3 | |
| SCHEMBL21801230 | 0.80 | CYP3A4 (0.41) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849966-B1 | FLAVONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | HOFFMANN LA ROCHE (CH) | 2023-10-25 | — | — | EP | disclosed |
| WO-2020052774-A1 | FLAVONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-03-19 | — | — | WO | disclosed |
| WO-2020053249-A1 | FLAVONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-03-19 | — | — | WO | disclosed |