Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21869796 | 0.92 | P2RX7 (0.54) | GAAPOLBKMT2ACYP2D6CYP2C19 | |
| SCHEMBL28650737 | 0.92 | P2RX7 (0.54) | GAAPOLBKMT2ACYP2D6CYP2C19 | |
| SCHEMBL21869790 | 0.91 | GAA (0.62) | GAAPOLBKMT2ACYP2D6CYP2C19 | |
| SCHEMBL21869797 | 0.91 | GAA (0.49) | GAAPOLBKMT2ACYP2D6CYP2C19 | |
| SCHEMBL21869799 | 0.89 | ITGB1 (0.52) | KMT2AHDAC1HDAC2P2RX7 | |
| SCHEMBL21869800 | 0.89 | HCRTR2 (0.52) | GAAPOLBKMT2ACYP2D6CYP2C19 | |
| SCHEMBL21869753 | 0.88 | KMT2A (0.63) | GAAKMT2ACYP2C19ALDH1A1CYP2C9 | |
| SCHEMBL21869791 | 0.88 | GAA (0.49) | GAAPOLBKMT2ACYP2D6CYP2C19 | |
| SCHEMBL21869759 | 0.86 | KMT2A (0.49) | KMT2AHCRTR2HDAC1HCRTR1 | |
| SCHEMBL6997222 | 0.85 | GAA (0.58) | GAAPOLBKMT2ACYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109180552-B | Substituted 5-oxo pyrrolidine derivative and preparation method and application thereof | 沈阳药科大学 | 2021-10-26 | — | — | CN | disclosed |
| WO-2020063388-A1 | SUBSTITUTED 5-OXOPYRROLIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 沈阳药科大学 | 2020-04-02 | — | — | WO | disclosed |