Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 5/20 | 0.52 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21869824 | 0.95 | FKBP1A (0.53) | ITGB1ITGA4HDAC1HDAC6FKBP1A | |
| SCHEMBL28663248 | 0.95 | FKBP1A (0.53) | ITGB1ITGA4HDAC1HDAC6FKBP1A | |
| SCHEMBL28650737 | 0.90 | P2RX7 (0.54) | HDAC1HDAC6FKBP1AKMT2AP2RX7 | |
| SCHEMBL21869796 | 0.90 | P2RX7 (0.54) | HDAC1HDAC6FKBP1AKMT2AP2RX7 | |
| SCHEMBL21869798 | 0.90 | KMT2A (0.62) | HDAC1HDAC6FKBP1AKMT2A | |
| SCHEMBL28663232 | 0.90 | KMT2A (0.62) | HDAC1HDAC6FKBP1AKMT2A | |
| SCHEMBL21869794 | 0.90 | HDAC1 (0.50) | ITGB1ITGA4HDAC1HDAC6FKBP1A | |
| SCHEMBL21869747 | 0.90 | KMT2A (0.62) | HDAC1HDAC6FKBP1AKMT2A | |
| SCHEMBL21869801 | 0.89 | GAA (0.51) | HDAC1KMT2AP2RX7HDAC2 | |
| SCHEMBL21869753 | 0.89 | KMT2A (0.63) | ITGB1ITGA4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109180552-B | Substituted 5-oxo pyrrolidine derivative and preparation method and application thereof | 沈阳药科大学 | 2021-10-26 | — | — | CN | disclosed |
| WO-2020063388-A1 | SUBSTITUTED 5-OXOPYRROLIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 沈阳药科大学 | 2020-04-02 | — | — | WO | disclosed |