Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 3/20 | 0.62 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.56 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186444 | 0.86 | CSNK1E (0.79) | CSNK1ECSNK1DCSNK1G3NPC1LMNA | |
| SCHEMBL11705432 | 0.78 | IRAK4 (0.58) | NPC1LMNATP53PKMGAA | |
| SCHEMBL27756403 | 0.76 | IRAK4 (0.56) | NPC1PKMKMT2ARAB9AMEN1 | |
| SCHEMBL28775420 | 0.75 | CSNK1E (0.84) | CSNK1ECSNK1DCSNK1G3NPC1LMNA | |
| SCHEMBL3603343 | 0.75 | NPC1 (0.64) | NPC1LMNATP53PKMGAA | |
| SCHEMBL16789309 | 0.75 | CSNK1E (0.82) | CSNK1ECSNK1DCSNK1G3NPC1PKM | |
| SCHEMBL3604259 | 0.74 | RAB9A (0.70) | NPC1LMNATP53PKMGAA | |
| SCHEMBL27756405 | 0.73 | CSNK1E (0.56) | CSNK1ECSNK1DCSNK1G3NPC1LMNA | |
| SCHEMBL27756547 | 0.73 | CSNK1E (0.55) | CSNK1ECSNK1DCSNK1G3NPC1LMNA | |
| SCHEMBL11706898 | 0.73 | NPC1 (1.00) | NPC1LMNATP53PKMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |