Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21542308 | 0.90 | ALDH1A1 (0.65) | POLBLMNATSHRSMN1; SMN2GPR119 | |
| SCHEMBL1778856 | 0.88 | POLB (0.69) | POLBLMNAUSP2TSHRSMN1; SMN2 | |
| SCHEMBL5235386 | 0.86 | ALDH1A1 (0.60) | POLBLMNATSHRSMN1; SMN2GPR119 | |
| SCHEMBL10993938 | 0.85 | POLB (0.90) | POLBLMNAUSP2TSHRSMN1; SMN2 | |
| SCHEMBL27679658 | 0.85 | POLB (0.71) | POLBLMNAUSP2TSHRSMN1; SMN2 | |
| SCHEMBL25168131 | 0.84 | POLB (0.55) | POLBLMNAUSP2TSHRSMN1; SMN2 | |
| SCHEMBL30410566 | 0.84 | POLB (0.55) | POLBLMNAUSP2TSHRSMN1; SMN2 | |
| SCHEMBL3849025 | 0.83 | GPR119 (0.56) | POLBLMNAUSP2SMN1; SMN2GPR119 | |
| SCHEMBL3097876 | 0.82 | POLB (0.76) | POLBLMNAUSP2TSHRSMN1; SMN2 | |
| SCHEMBL30372037 | 0.82 | POLB (0.53) | POLBLMNAUSP2TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |