⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4236 | 1.00 | — | — | |
| SCHEMBL13921120 | 0.97 | SMN1; SMN2 (1.00) | — | |
| SCHEMBL13173709 | 0.97 | SMN1; SMN2 (1.00) | — | |
| SCHEMBL19985902 | 0.97 | SMN1; SMN2 (1.00) | — | |
| Hydrochloric Acid SCHEMBL5485891 | 0.97 | SMN1; SMN2 (0.90) | — | |
| SCHEMBL14590546 | 0.91 | SMN1; SMN2 (0.78) | — | |
| SCHEMBL12409426 | 0.91 | SMN1; SMN2 (0.78) | — | |
| Methane SCHEMBL11856508 | 0.87 | SMN1; SMN2 (0.72) | — | |
| Morpholine SCHEMBL29136408 | 0.87 | SMN1; SMN2 (0.72) | — | |
| SCHEMBL7742546 | 0.87 | SMN1; SMN2 (0.72) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342203-B1 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2015-11-04 | — | — | EP | disclosed |
| US-9006238-B2 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2015-04-14 | — | — | US | disclosed |
| US-20130158027-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2013-06-20 | — | — | US | disclosed |
| US-8455486-B2 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SA (CH) | 2013-06-04 | — | — | US | disclosed |
| US-20110178082-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2011-07-21 | — | — | US | disclosed |
| EP-2342203-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GenKyoTex SA (CH) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010035220-A1 | PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS | GENKYOTEX SA (CH) | 2010-04-01 | — | — | WO | disclosed |
| US-3957766-A | BACTERIOSTATS, BACTERICIDES | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1976-05-18 | — | — | US | disclosed |