Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Morin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.64 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 8/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.76 |
| ▸ | XDH | P47989 | 6/20 | 0.76 |
| ▸ | MAPT | P10636 | 6/20 | 0.76 |
| ▸ | FTO | Q9C0B1 | 6/20 | 0.76 |
| ▸ | APP | P05067 | 5/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.76 |
| ▸ | POLB | P06746 | 5/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | HPGD | P15428 | 4/20 | 0.76 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.76 |
| ▸ | DAPK1 | P53355 | 4/20 | 0.76 |
| ▸ | BACE1 | P56817 | 4/20 | 0.76 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morin SCHEMBL10335390 | 0.87 | MEN1 (1.00) | MEN1KMT2ACYP3A4CYP2C9XDH | |
| Morin SCHEMBL29435805 | 0.87 | MEN1 (1.00) | MEN1KMT2ACYP3A4CYP2C9XDH | |
| Morin SCHEMBL29929115 | 0.87 | MEN1 (1.00) | MEN1KMT2ACYP3A4CYP2C9XDH | |
| Morin SCHEMBL19984 | 0.87 | MEN1 (1.00) | MEN1KMT2ACYP3A4CYP2C9XDH | |
| Morin SCHEMBL29400568 | 0.86 | MPG (1.00) | MEN1KMT2ACYP3A4CYP2C9XDH | |
| Morin SCHEMBL21874430 | 0.86 | MEN1 (0.97) | MEN1KMT2ACYP3A4CYP2C9XDH | |
| Morin SCHEMBL7116848 | 0.86 | MPG (1.00) | MEN1KMT2ACYP3A4CYP2C9XDH | |
| Morin SCHEMBL294933 | 0.86 | MPG (1.00) | MEN1KMT2ACYP3A4CYP2C9XDH | |
| Morin SCHEMBL15106661 | 0.86 | MPG (1.00) | MEN1KMT2ACYP3A4CYP2C9XDH | |
| Morin SCHEMBL11734524 | 0.85 | MEN1 (0.80) | MEN1KMT2ACYP3A4CYP2C9XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210379087-A1 | COMPOSITIONS FOR THE ELIMINATION OF SENESCENT CELLS | MEDIZINISCHE UNIVERSITÄT WIEN (AT) | 2021-12-09 | — | — | US | claimed |
| CN-113347969-A | Composition for eliminating senescent cells | 维也纳自然资源与生命科学大学 | 2021-09-03 | — | — | CN | claimed |
| EP-3643305-A1 | COMPOSITIONS FOR THE ELIMINATION OF SENESCENT CELLS | Universität für Bodenkultur Wien (AT) | 2020-04-29 | — | — | EP | claimed |
| US-20210379087-A1 | COMPOSITIONS FOR THE ELIMINATION OF SENESCENT CELLS | MEDIZINISCHE UNIVERSITÄT WIEN (AT) | 2021-12-09 | — | — | US | disclosed |
| CN-113347969-A | Composition for eliminating senescent cells | 维也纳自然资源与生命科学大学 | 2021-09-03 | — | — | CN | disclosed |
| EP-3643305-A1 | COMPOSITIONS FOR THE ELIMINATION OF SENESCENT CELLS | Universität für Bodenkultur Wien (AT) | 2020-04-29 | — | — | EP | disclosed |