Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2185860 | 0.85 | KMT2A (0.56) | LMNAHTTTSHRNPSR1ALDH1A1 | |
| SCHEMBL2186831 | 0.82 | TSHR (0.44) | LMNAHTTTSHRNPSR1ALDH1A1 | |
| SCHEMBL2188423 | 0.79 | CSNK1E (0.56) | LMNAHTTTSHRNPSR1ALDH1A1 | |
| SCHEMBL2188562 | 0.79 | LMNA (0.67) | LMNAHTTTSHRNPSR1L3MBTL1 | |
| SCHEMBL2189086 | 0.77 | LMNA (0.49) | LMNAHTTTSHRNPSR1ALDH1A1 | |
| SCHEMBL2185882 | 0.77 | LMNA (0.60) | LMNAHTTTSHRNPSR1ALDH1A1 | |
| SCHEMBL27756397 | 0.76 | LMNA (0.55) | LMNAHTTTSHRNPSR1ALDH1A1 | |
| SCHEMBL2187871 | 0.75 | LMNA (0.54) | LMNAHTTTSHRNPSR1ALDH1A1 | |
| SCHEMBL2187066 | 0.74 | LMNA (0.58) | LMNAHTTTSHRNPSR1ALDH1A1 | |
| SCHEMBL2185460 | 0.74 | KMT2A (0.57) | LMNAHTTTSHRNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101031567-B | Novel heterocyclic NF-kB inhibitors | 4SC Corp.,Ltd. (DE) | 2011-12-21 | — | — | CN | disclosed |
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |
| CN-101405278-A | Novel heterocyclic NF-kB inhibitors | 4SC AG (DE) | 2009-04-08 | — | — | CN | disclosed |
| CN-101233119-A | Novel heterocyclic nf-kb inhibitors | 4SC AG (DE) | 2008-07-30 | — | — | CN | disclosed |
| CN-101031567-A | Novel heterocyclic NF-kB inhibitors | 4SC AG (DE) | 2007-09-05 | — | — | CN | disclosed |