Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.67 |
| ▸ | TSHR | P16473 | 5/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NCS1 | P62166 | 1/20 | 0.50 |
| ▸ | PHGDH | O43175 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2188423 | 0.92 | CSNK1E (0.56) | LMNATSHRHSD17B10ALOX15USP2 | |
| SCHEMBL2187871 | 0.83 | LMNA (0.54) | LMNATSHRHSD17B10ALOX15USP2 | |
| SCHEMBL2187121 | 0.81 | CSNK1E (0.48) | LMNATSHRPOLBMAPTHTT | |
| SCHEMBL2188984 | 0.81 | LMNA (0.62) | LMNATSHRHSD17B10ALOX15USP2 | |
| SCHEMBL2187965 | 0.79 | LMNA (0.51) | LMNATSHRHSD17B10TP53POLB | |
| SCHEMBL2187098 | 0.79 | CSNK1E (0.51) | LMNATSHRHSD17B10USP2POLB | |
| SCHEMBL2188622 | 0.79 | CSNK1E (0.53) | HSD17B10ALOX15USP2TP53MAPT | |
| SCHEMBL2187509 | 0.77 | LMNA (0.57) | LMNATSHRHSD17B10ALOX15USP2 | |
| SCHEMBL2188767 | 0.77 | LMNA (0.62) | LMNATSHRHSD17B10ALOX15USP2 | |
| SCHEMBL2189086 | 0.77 | LMNA (0.49) | LMNATSHRHSD17B10POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |