SCHEMBL21879873

SCHEMBL21879873

C=Cc1nc(Br)c(C(=O)NC2CN(C(=O)O)C2)n1C

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KRAS P01116 3/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21880100 0.84 USP30 (0.43) KRAS
SCHEMBL23930961 0.78
SCHEMBL23930845 0.75 GPR35 (0.33)
SCHEMBL23930977 0.74 USP30 (0.44)
SCHEMBL21879955 0.72 NPC1 (0.30)
SCHEMBL21879961 0.71 KRAS (0.31) KRAS
SCHEMBL23930858 0.70 NPSR1 (0.34)
SCHEMBL21879836 0.67 LMNA (0.39) LMNA
SCHEMBL21880055 0.66 CNR2 (0.32)
SCHEMBL21880015 0.65 APOBEC3A (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020085493-A1 NOVEL INDAZOLE COMPOUND OR SALT THEREOF 大鵬薬品工業株式会社 2020-04-30 WO disclosed