SCHEMBL2188155

SCHEMBL2188155

Cc1ccc(O)c([Si](C)(C)C)c1S(=O)(=O)O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.35
HSD17B10 Q99714 3/20 0.35
TDP1 Q9NUW8 2/20 0.35
GAA P10253 2/20 0.35
RECQL P46063 2/20 0.35
HPGD P15428 2/20 0.35
TP53 P04637 1/20 0.35
GLA P06280 1/20 0.35
CYP3A4 P08684 1/20 0.35
NT5E P21589 1/20 0.35
CASP1 P29466 1/20 0.35
CASP7 P55210 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
POLB P06746 2/20 0.33
KDM4E B2RXH2 1/20 0.33
APEX1 P27695 1/20 0.33
PKM P14618 1/20 0.33
ESR2 Q92731 1/20 0.31
RPS6KA3 P51812 1/20 0.31
OPRK1 P41145 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6865520 0.80 TDP1 (0.35) ALDH1A1HSD17B10TDP1GAARECQL
SCHEMBL14126563 0.77 KMT2A (0.36) ALDH1A1HSD17B10TDP1GAARECQL
SCHEMBL5202112 0.76 TRPA1 (0.38) ALDH1A1HSD17B10TDP1GAARECQL
SCHEMBL301470 0.76 RPS6KA3 (0.41) ALDH1A1HSD17B10TDP1GAARECQL
SCHEMBL10346665 0.76 POLB (0.32) ALDH1A1HSD17B10TDP1GAARECQL
SCHEMBL16343725 0.75 ALDH1A1 (0.41) ALDH1A1HSD17B10TDP1GAARECQL
SCHEMBL5189655 0.72 TRPA1 (0.38) ALDH1A1HSD17B10TDP1GAARECQL
SCHEMBL19194608 0.72 TRPA1 (0.38) ALDH1A1HSD17B10TDP1GAARECQL
SCHEMBL1808650 0.71 ALDH1A1 (0.40) ALDH1A1HSD17B10TDP1GAARECQL
SCHEMBL4208635 0.70 ESR1 (0.39) ALDH1A1HSD17B10TDP1GAARECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2031031-B1 Use of a latent acid for improving adhesion SIKA TECHNOLOGY AG (CH) 2011-07-13 EP claimed
EP-2031031-A1 Use of a latent acid for improving adhesion Sika Technology AG (CH) 2009-03-04 EP claimed
EP-0143323-B1 PROCESS FOR AN ANTHRACYCLINE DERIVATIVE, AND AN ANTHRACYCLINONE DERIVATIVE USEFUL FOR THE PROCESS SAGAMI CHEMICAL RESEARCH CENTER (JP) 1988-10-26 EP claimed
EP-2031031-B1 Use of a latent acid for improving adhesion SIKA TECHNOLOGY AG (CH) 2011-07-13 EP disclosed
EP-2031031-A1 Use of a latent acid for improving adhesion Sika Technology AG (CH) 2009-03-04 EP disclosed