Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.48 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.48 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.48 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.48 |
| ▸ | ATF4 | P18848 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25215479 | 0.91 | GPR84 (0.49) | GPR84SMN1; SMN2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL2094457 | 0.85 | ATF4 (0.48) | GPR84SMN1; SMN2ATF4PPARGPPARA | |
| SCHEMBL3525094 | 0.83 | GPR84 (0.51) | GPR84ATF4PPARGPPARAHRH3 | |
| SCHEMBL9451250 | 0.82 | SMN1; SMN2 (0.67) | GPR84SMN1; SMN2ALDH1A1RECQLTP53 | |
| SCHEMBL21490294 | 0.82 | MAOB (0.49) | SMN1; SMN2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL29450668 | 0.82 | SMN1; SMN2 (0.67) | GPR84SMN1; SMN2ALDH1A1RECQLTP53 | |
| SCHEMBL30368255 | 0.82 | MAOB (0.49) | SMN1; SMN2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL17433278 | 0.81 | GPR84 (0.50) | GPR84ATF4ALDH1A1RECQLHTR1A | |
| SCHEMBL95960 | 0.81 | GPR84 (0.50) | GPR84SMN1; SMN2ATF4HTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL15512062 | 0.81 | GPR84 (0.50) | GPR84SMN1; SMN2ATF4PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11166942-B2 | Inhibitors of integrated stress response pathway | Praxis Biotech LLC (US) | 2021-11-09 | — | — | US | disclosed |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2020-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11166942-B2 | Inhibitors of integrated stress response pathway | ATF4, DDIT3, ATF1 | GPR84 3616/4885SMN1; SMN2 3465/4885PRKAB2 239/4885 |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | GPR84 3616/4885SMN1; SMN2 3465/4885PRKAB2 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.