Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18055529 | 0.86 | PPARA (0.56) | PPARGPPARA | |
| SCHEMBL28171714 | 0.85 | PPARA (0.54) | PPARGPPARA | |
| SCHEMBL19912667 | 0.85 | PPARA (0.56) | PTPN1PPARGPPARA | |
| SCHEMBL19803711 | 0.85 | PPARA (0.56) | PTPN1PPARGPPARA | |
| Lithium Ion SCHEMBL18039148 | 0.84 | MEN1 (0.44) | MEN1KMT2ANAMPTMAPTMAPK1 | |
| SCHEMBL23809782 | 0.83 | HTRA1 (0.47) | ALDH1A1MAPTPTPN1MAPK1PPARG | |
| SCHEMBL19912668 | 0.83 | HTRA1 (0.47) | ALDH1A1MAPTPTPN1MAPK1PPARG | |
| SCHEMBL11364236 | 0.74 | PPARG (0.52) | MEN1KMT2APOLBHPGDPPARG | |
| SCHEMBL16508902 | 0.74 | TBXAS1 (0.57) | KMT2ANLRP3HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL21016946 | 0.73 | HTRA1 (0.53) | NLRP3PTPN1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262026-B1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2020-03-18 | — | — | EP | disclosed |