Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 5/20 | 0.47 |
| ▸ | PPARG | P37231 | 7/20 | 0.46 |
| ▸ | PPARA | Q07869 | 7/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | OGG1 | O15527 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19912668 | 1.00 | HTRA1 (0.47) | HTRA1PPARGPPARAPNMTPTPN1 | |
| SCHEMBL19803711 | 0.89 | PPARA (0.56) | HTRA1PPARGPPARAPTPN1 | |
| SCHEMBL19912667 | 0.89 | PPARA (0.56) | HTRA1PPARGPPARAPTPN1 | |
| SCHEMBL19899295 | 0.85 | PPARA (0.62) | PPARGPPARA | |
| SCHEMBL19803593 | 0.85 | PPARA (0.62) | PPARGPPARA | |
| SCHEMBL21882677 | 0.83 | MEN1 (0.46) | PPARGPPARAPTPN1MAPTMAPK1 | |
| SCHEMBL15446256 | 0.82 | PNMT (0.51) | PPARGPPARAPNMTMAPTMAPK1 | |
| SCHEMBL21016946 | 0.81 | HTRA1 (0.53) | HTRA1PPARGPPARAPTPN1MRGPRX4 | |
| SCHEMBL19803698 | 0.80 | PPARA (0.46) | HTRA1PPARGPPARAPNMTMRGPRX4 | |
| SCHEMBL21016630 | 0.80 | PPARA (0.56) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484859-B1 | NEW DIFLUOROKETAMIDE DERIVATIVES AS HTRA1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-09-15 | — | — | EP | disclosed |