Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.35 |
| ▸ | PDE4A | P27815 | 4/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21883563 | 0.84 | NAMPT (0.36) | NLRP3PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL19779564 | 0.80 | PDE4D (0.47) | NLRP3MAPTPDE4BPDE4DPDE4A | |
| SCHEMBL20621278 | 0.79 | TSHR (0.40) | NLRP3TSHRMAPTPDE4BPDE4D | |
| SCHEMBL19780139 | 0.77 | KMT2A (0.33) | NLRP3L3MBTL1MAPTPDE4BPDE4D | |
| SCHEMBL20621414 | 0.77 | NLRP3 (0.54) | NLRP3TSHRL3MBTL1PDE4DALOX15 | |
| SCHEMBL21883543 | 0.77 | PKM (0.39) | NLRP3MAPTSMN1; SMN2KDM4EUSP2 | |
| SCHEMBL19780140 | 0.76 | PDE4A (0.38) | NLRP3TSHRL3MBTL1MAPTPDE4B | |
| SCHEMBL22096836 | 0.75 | PDE4D (0.37) | NLRP3L3MBTL1PDE4BPDE4DPDE4A | |
| SCHEMBL19768991 | 0.75 | NLRP3 (0.35) | NLRP3PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL11656445 | 0.69 | NLRP3 (0.63) | NLRP3TSHRMAPTALOX15KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597377-B2 | Somatostatin modulators and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2020-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10597377-B2 | Somatostatin modulators and uses thereof | SSTR5, SSTR2, SSTR4 | NLRP3 3808/4885TSHR 70/4885L3MBTL1 4271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.