Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 10/20 | 0.37 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 4/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | PPIA | P62937 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21884641 | 0.93 | TMPRSS4 (0.40) | S1PR3TMPRSS4S1PR1P2RX1TAS1R3 | |
| SCHEMBL21884530 | 0.87 | TMPRSS4 (0.40) | S1PR3TMPRSS4P2RX1ADRA1DP2RX4 | |
| SCHEMBL21884417 | 0.85 | PPIA (0.35) | P2RX1TAS1R3TAS1R1TAS1R2PPIA | |
| SCHEMBL23854851 | 0.85 | PPIA (0.36) | S1PR3P2RX1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL21884788 | 0.84 | PPIA (0.40) | CNR2PPIA | |
| SCHEMBL21884443 | 0.83 | PPIA (0.38) | S1PR3P2RX1CNR2PPIA | |
| SCHEMBL21884534 | 0.83 | PPIA (0.35) | S1PR3S1PR1CNR2S1PR4PPIA | |
| SCHEMBL21885702 | 0.83 | PPIA (0.35) | S1PR3TMPRSS4P2RX1TAS1R3TAS1R1 | |
| SCHEMBL21884581 | 0.82 | KCNMA1 (0.42) | S1PR3TMPRSS4S1PR1 | |
| SCHEMBL21884447 | 0.82 | CNR2 (0.35) | S1PR3TMPRSS4P2RX1ADRA1DP2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210371403-A1 | SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS | JNANA THERAPEUTICS INC. | 2021-12-02 | — | — | US | disclosed |
| US-20210299070-A1 | METHODS OF TREATING CREATINE TRANSPORTER DEFICIENCY | JNANA THERAPEUTICS INC. | 2021-09-30 | — | — | US | disclosed |
| US-20210299070-A1 | METHODS OF TREATING CREATINE TRANSPORTER DEFICIENCY | JNANA THERAPEUTICS INC. | 2021-09-30 | — | — | US | disclosed |
| WO-2020061473-A1 | SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS | JNANA THERAPEUTICS, INC. (US) | 2020-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210299070-A1 | METHODS OF TREATING CREATINE TRANSPORTER DEFICIENCY | SLC19A1, SLC1A5, SLC1A2 | S1PR3 1595/4885TMPRSS4 1380/4885S1PR1 1587/4885 |
| US-20210371403-A1 | SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS | SNRPE, G3BP1, G3BP2 | S1PR3 3963/4885TMPRSS4 3136/4885S1PR1 3943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.