Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.42 |
| ▸ | STK10 | O94804 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | HCK | P08631 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30365215 | 0.89 | KDR (0.60) | KDRPDGFRBALDH1A1FGFR1CYP3A4 | |
| SCHEMBL18265407 | 0.84 | KDR (0.56) | KDRPDGFRBFGFR1CYP3A4EPHB6 | |
| SCHEMBL21884884 | 0.83 | KDR (0.75) | KDRPDGFRBFGFR1EPHB6RIPK2 | |
| SCHEMBL21806043 | 0.83 | KDR (0.59) | KDRPDGFRBFGFR1CYP3A4EPHB6 | |
| SCHEMBL21805901 | 0.82 | KDR (0.54) | KDRPDGFRBFGFR1CYP3A4EPHB6 | |
| SCHEMBL21884846 | 0.81 | KDM4E (0.46) | KDRPDGFRBKDM4EMEN1ALDH1A1 | |
| SCHEMBL21659077 | 0.81 | KDR (0.60) | KDRPDGFRBALDH1A1FGFR1EPHB6 | |
| SCHEMBL21884868 | 0.80 | KDR (0.60) | KDRPDGFRBFGFR1EPHB6RIPK2 | |
| SCHEMBL22328212 | 0.80 | KDR (0.60) | KDRPDGFRBFGFR1CYP3A4EPHB6 | |
| SCHEMBL18265416 | 0.80 | KDR (0.77) | KDRPDGFRBFGFR1EPHB6RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112996784-B | Indole derivatives and their use in medicine | 北京越之康泰生物医药科技有限公司 | 2023-05-30 | — | — | CN | disclosed |
| WO-2020057403-A1 | INDOLE DERIVATIVE AND MEDICAL APPLICATION THEREOF | 北京越之康泰生物医药科技有限公司 | 2020-03-26 | — | — | WO | disclosed |