Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | MET | P08581 | 5/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | GAK | O14976 | 1/20 | 0.45 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | STK10 | O94804 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21884830 | 1.00 | KDR (0.56) | KDRPDGFRBMETEGFRRET | |
| SCHEMBL21884832 | 0.91 | KDR (0.45) | KDRPDGFRBMETAXLSRC | |
| SCHEMBL30365200 | 0.88 | KDR (0.58) | KDRPDGFRBMETEGFRRET | |
| SCHEMBL30365337 | 0.88 | KDR (0.58) | KDRPDGFRBMETEGFRRET | |
| SCHEMBL21884825 | 0.88 | KDR (0.58) | KDRPDGFRBMETEGFRRET | |
| SCHEMBL21884860 | 0.88 | KDR (0.58) | KDRPDGFRBMETEGFRRET | |
| SCHEMBL21884863 | 0.86 | KDR (0.62) | KDRPDGFRBMETEGFRRET | |
| SCHEMBL21886117 | 0.85 | KDR (0.58) | KDRPDGFRBMETEGFRRET | |
| SCHEMBL30365379 | 0.85 | KDR (0.58) | KDRPDGFRBMETEGFRRET | |
| SCHEMBL21885588 | 0.84 | KDR (0.61) | KDRPDGFRBMETEGFRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020057403-A1 | INDOLE DERIVATIVE AND MEDICAL APPLICATION THEREOF | 北京越之康泰生物医药科技有限公司 | 2020-03-26 | — | — | WO | disclosed |