Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | APLNR | P35414 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30526995 | 0.84 | MAPK8 (0.44) | MAPK8APLNRGRM5SMN1; SMN2KCNK3 | |
| SCHEMBL30526992 | 0.84 | APLNR (0.54) | MAPK8APLNRSMN1; SMN2KCNK3KCNK9 | |
| SCHEMBL23026124 | 0.84 | MAPK8 (0.44) | MAPK8APLNRGRM5SMN1; SMN2KCNK3 | |
| SCHEMBL23026167 | 0.84 | APLNR (0.54) | MAPK8APLNRSMN1; SMN2KCNK3KCNK9 | |
| SCHEMBL21886277 | 0.79 | APLNR (0.39) | APLNRSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL20207309 | 0.71 | GRM4 (0.41) | SMN1; SMN2RAB9AMAPTALDH1A1KDM4E | |
| SCHEMBL21826864 | 0.71 | APLNR (0.42) | MAPK8APLNRGRM5SMN1; SMN2MEN1 | |
| SCHEMBL31471124 | 0.71 | APLNR (0.42) | MAPK8APLNRGRM5SMN1; SMN2KCNK3 | |
| SCHEMBL21826883 | 0.71 | APLNR (0.42) | MAPK8APLNRGRM5SMN1; SMN2KCNK3 | |
| SCHEMBL31471102 | 0.71 | APLNR (0.42) | MAPK8APLNRGRM5SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020073011-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH APJ RECEPTOR ACTIVITY | ANNAPURNA BIO, INC. (US) | 2020-04-09 | — | — | WO | disclosed |