Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC1 | P33527 | 2/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 8/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21886454 | 0.90 | ABCB1 (0.47) | ABCC1ABCG2CYP1B1ABCB1CYP1A1 | |
| SCHEMBL21865645 | 0.89 | CYP1B1 (0.46) | ABCC1ABCG2CYP1B1ABCB1CYP1A1 | |
| SCHEMBL21801140 | 0.87 | ABCC1 (0.57) | ABCC1ABCG2CYP1B1ABCB1CYP1A1 | |
| SCHEMBL30744120 | 0.87 | ABCC1 (0.57) | ABCC1ABCG2CYP1B1ABCB1CYP1A1 | |
| SCHEMBL21801217 | 0.81 | SIGMAR1 (0.39) | ABCC1ABCG2CYP1B1CYP1A1CYP1A2 | |
| SCHEMBL21801254 | 0.81 | SIGMAR1 (0.39) | ABCC1ABCG2CYP1B1CYP1A1CYP1A2 | |
| SCHEMBL21865746 | 0.79 | CSNK2A2 (0.44) | ABCC1ABCG2CYP1B1ABCB1CYP1A1 | |
| SCHEMBL30744133 | 0.79 | ABCB1 (0.58) | ABCC1ABCG2CYP1B1ABCB1CYP1A1 | |
| SCHEMBL21801245 | 0.79 | ABCB1 (0.58) | ABCC1ABCG2CYP1B1ABCB1CYP1A1 | |
| SCHEMBL22231441 | 0.77 | ABCB1 (0.52) | ABCC1ABCG2CYP1B1ABCB1CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849966-B1 | FLAVONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | HOFFMANN LA ROCHE (CH) | 2023-10-25 | — | — | EP | disclosed |
| WO-2020052774-A1 | FLAVONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-03-19 | — | — | WO | disclosed |