SCHEMBL21886800

SCHEMBL21886800

Cc1cn([C@@H]2C[C@H](O)[C@@H](COC(=O)c3ccccc3)O2)c(=O)[nH]c1=O

nearest known ligand 0.67

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
RNASE1 P07998 1/20 0.67
POLB P06746 1/20 0.58
TK1 P04183 2/20 0.58
BCHE P06276 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4731692 1.00 RNASE1 (0.67) RNASE1POLBTK1BCHE
SCHEMBL4731694 1.00 RNASE1 (0.67) RNASE1POLBTK1BCHE
SCHEMBL21886792 1.00 RNASE1 (0.67) RNASE1POLBTK1BCHE
SCHEMBL5040039 0.93 TYMS (0.60) RNASE1POLBTK1
SCHEMBL2584183 0.93 TYMS (0.60) RNASE1POLBTK1
SCHEMBL9012072 0.90 POLB (0.57) RNASE1POLBTK1
SCHEMBL5709916 0.90 POLB (0.57) RNASE1POLBTK1
SCHEMBL9321729 0.90 POLB (0.57) RNASE1POLBTK1
SCHEMBL9321645 0.90 POLB (0.57) RNASE1POLBTK1
SCHEMBL25504768 0.90 RNASE1 (0.67) RNASE1TK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230159922-A1 MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF IONIS PHARMACEUTICALS, INC. (US) 2023-05-25 US disclosed
US-20230159922-A1 MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF IONIS PHARMACEUTICALS, INC. (US) 2023-05-25 US disclosed
WO-2021030763-A1 MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF IONIS PHARMACEUTICALS, INC. (US) 2021-02-18 WO disclosed
WO-2020072991-A1 MODIFIED OLIGOMERIC COMPOUNDS AND USES THEREOF IONIS PHARMACEUTICALS, INC. (US) 2020-04-09 WO disclosed