Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21834760 | 0.82 | KDM4E (0.44) | ALDH1A1KDM4ESMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL22552021 | 0.75 | ALDH1A1 (0.48) | ALDH1A1KDM4ESMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL22717706 | 0.74 | ALDH1A1 (0.51) | ALDH1A1KDM4ESMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL2337541 | 0.74 | SMN1; SMN2 (0.44) | ALDH1A1KDM4ESMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL12462778 | 0.73 | MTOR (0.56) | ALDH1A1KDM4ESMN1; SMN2RXFP1L3MBTL1 | |
| SCHEMBL13828586 | 0.72 | SMN1; SMN2 (0.42) | ALDH1A1KDM4ESMN1; SMN2TDP1MEN1 | |
| SCHEMBL21886932 | 0.72 | NPSR1 (0.48) | ALDH1A1KDM4ESMN1; SMN2MAPK1MAPT | |
| SCHEMBL23804783 | 0.72 | SMN1; SMN2 (0.51) | ALDH1A1KDM4ESMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL2534706 | 0.72 | SMN1; SMN2 (0.46) | ALDH1A1KDM4ESMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL26079031 | 0.71 | PIK3CA (0.60) | ALDH1A1KDM4ESMN1; SMN2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110950868-B | Pyrazolopyrimidine compound, preparation method thereof and application of pyrazolopyrimidine compound in preparation of anti-cancer drugs | 苏州锐明新药研发有限公司 | 2022-05-13 | — | — | CN | disclosed |
| US-20210340146-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | SUZHOU RAYMON PHARMACEUTICALS COMPANY LTD (CN) | 2021-11-04 | — | — | US | disclosed |
| CN-110950868-A | Pyrazolopyrimidine compound, preparation method thereof and application thereof in preparing anti-cancer drugs | 苏州锐明新药研发有限公司 | 2020-04-03 | — | — | CN | disclosed |
| WO-2020063636-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | 苏州锐明新药研发有限公司 | 2020-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210340146-A1 | PYRAZOLOPYRIMIDINE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF ANTI-CANCER DRUG | PIK3CA, PIK3CD, PIK3R5 | ALDH1A1 1096/4885KDM4E 2769/4885SMN1; SMN2 4491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.