Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.75 |
| ▸ | NPC1 | O15118 | 8/20 | 0.75 |
| ▸ | RAB9A | P51151 | 8/20 | 0.75 |
| ▸ | POLB | P06746 | 5/20 | 0.75 |
| ▸ | MEN1 | O00255 | 7/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31236779 | 0.86 | NPC1 (1.00) | MAPTNPC1RAB9APOLBMEN1 | |
| SCHEMBL21887603 | 0.81 | MAPT (0.68) | MAPTNPC1RAB9APOLBMEN1 | |
| SCHEMBL23698298 | 0.77 | ALDH1A1 (0.60) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL23698299 | 0.77 | ALDH1A1 (0.60) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL17044520 | 0.76 | MEN1 (0.50) | MAPTNPC1RAB9APOLBMEN1 | |
| SCHEMBL17044522 | 0.76 | MEN1 (0.50) | MAPTNPC1RAB9APOLBMEN1 | |
| Hydrochloric Acid SCHEMBL5703018 | 0.75 | MEN1 (0.49) | MAPTNPC1RAB9APOLBMEN1 | |
| Hydrochloric Acid SCHEMBL5703022 | 0.75 | MEN1 (0.49) | MAPTNPC1RAB9APOLBMEN1 | |
| SCHEMBL21887100 | 0.73 | TDP1 (0.49) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL24185000 | 0.72 | POLB (0.78) | MAPTNPC1RAB9APOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858342-A1 | ACYLHYDRAZONES FOR THE TREATMENT OF NEUROLOGICAL DISEASES | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2021-08-04 | — | — | EP | disclosed |
| WO-2020065119-A1 | ACYLHYDRAZONES FOR THE TREATMENT OF NEUROLOGICAL DISEASES | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2020-04-02 | — | — | WO | disclosed |