Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23698298 | 1.00 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL30714872 | 0.81 | MAPT (0.69) | ALDH1A1SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL23698306 | 0.81 | KMT2A (0.57) | ALDH1A1SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL23698305 | 0.81 | KMT2A (0.57) | ALDH1A1SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL21887104 | 0.80 | MAPT (0.67) | ALDH1A1SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL23698307 | 0.80 | MAPT (0.67) | ALDH1A1SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL30714864 | 0.77 | MAPT (0.61) | ALDH1A1SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL21887069 | 0.77 | MAPT (0.75) | ALDH1A1SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL8291982 | 0.77 | MAPT (0.66) | ALDH1A1SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL23698296 | 0.76 | MAPT (0.67) | ALDH1A1SMN1; SMN2RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858342-A1 | ACYLHYDRAZONES FOR THE TREATMENT OF NEUROLOGICAL DISEASES | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2021-08-04 | — | — | EP | claimed |
| EP-3858342-A1 | ACYLHYDRAZONES FOR THE TREATMENT OF NEUROLOGICAL DISEASES | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2021-08-04 | — | — | EP | disclosed |