Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.59 |
| ▸ | STAT3 | P40763 | 4/20 | 0.59 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21887786 | 0.93 | TYK2 (0.69) | TYK2STAT3HPGDS | |
| SCHEMBL21887371 | 0.91 | TYK2 (0.62) | TYK2STAT3HPGDS | |
| SCHEMBL30162010 | 0.91 | TYK2 (0.62) | TYK2STAT3HPGDS | |
| SCHEMBL22092671 | 0.88 | TYK2 (0.56) | TYK2STAT3HPGDS | |
| SCHEMBL22092695 | 0.87 | TYK2 (0.69) | TYK2STAT3 | |
| SCHEMBL21887372 | 0.84 | TDP1 (0.44) | TYK2 | |
| SCHEMBL28557220 | 0.82 | TYK2 (0.71) | TYK2STAT3HPGDS | |
| SCHEMBL21887375 | 0.80 | KDM4E (0.42) | — | |
| SCHEMBL21887376 | 0.79 | TYK2 (0.81) | TYK2STAT3 | |
| SCHEMBL30349442 | 0.79 | TYK2 (0.77) | TYK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849981-B1 | PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSORIASIS AND SYSTEMIC LUPUS ERYTHEMATOSUS | LILLY CO ELI (US) | 2023-02-01 | — | — | EP | disclosed |
| WO-2020055636-A1 | PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSORIASIS AND SYSTEMIC LUPUS ERYTHEMATOSUS | ELI LILLY AND COMPANY (US) | 2020-03-19 | — | — | WO | disclosed |