Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 18/20 | 0.56 |
| ▸ | STAT3 | P40763 | 4/20 | 0.56 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21887373 | 0.88 | TYK2 (0.59) | TYK2STAT3HPGDS | |
| SCHEMBL21887786 | 0.88 | TYK2 (0.69) | TYK2STAT3HPGDS | |
| SCHEMBL30377819 | 0.86 | TYK2 (0.62) | TYK2STAT3HPGDSPOLB | |
| SCHEMBL21887371 | 0.86 | TYK2 (0.62) | TYK2STAT3HPGDS | |
| SCHEMBL30162010 | 0.86 | TYK2 (0.62) | TYK2STAT3HPGDS | |
| SCHEMBL24987471 | 0.85 | POLB (0.46) | TYK2STAT3POLB | |
| SCHEMBL22092695 | 0.85 | TYK2 (0.69) | TYK2STAT3 | |
| SCHEMBL22092692 | 0.84 | POLB (0.44) | TYK2POLB | |
| SCHEMBL22092637 | 0.81 | KDM4E (0.41) | TYK2POLB | |
| SCHEMBL24224247 | 0.80 | TYK2 (0.78) | TYK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12060356-B2 | 7 (methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives | ELI LILLY AND COMPANY (US) | 2024-08-13 | — | — | US | disclosed |
| EP-3894412-B1 | 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | LILLY CO ELI (US) | 2023-02-08 | — | — | EP | disclosed |
| US-20220024933-A1 | 7 (METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | ELI LILLY AND COMPANY | 2022-01-27 | — | — | US | disclosed |
| EP-3894412-A1 | 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | Eli Lilly and Company (US) | 2021-10-20 | — | — | EP | disclosed |
| WO-2020123225-A1 | 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2020-06-18 | — | — | WO | disclosed |
| WO-2020123225-A1 | 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2020-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12060356-B2 | 7 (methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives | SSB, TLR7, TPMT | TYK2 57/4885STAT3 207/4885HPGDS 3826/4885 |
| US-20220024933-A1 | 7 (METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | SSB, TLR7, TPMT | TYK2 57/4885STAT3 207/4885HPGDS 3826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.