Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.33 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.32 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15935032 | 0.80 | ELOVL1 (0.44) | ELOVL1NR1H2NR1H3CYP2C9CYP2D6 | |
| SCHEMBL20242011 | 0.79 | ELOVL1 (0.43) | ELOVL1NR1H2NR1H3CYP2C9CYP2D6 | |
| SCHEMBL21819133 | 0.79 | ELOVL1 (0.38) | ELOVL1GABRA1GABRG2GABRB3NPC1 | |
| SCHEMBL15825472 | 0.79 | ELOVL1 (0.43) | ELOVL1NR1H2NR1H3CYP2C9CYP2D6 | |
| SCHEMBL30627857 | 0.79 | ELOVL1 (0.38) | ELOVL1GABRA1GABRG2GABRB3NPC1 | |
| SCHEMBL21888963 | 0.78 | IRAK4 (0.39) | GABRA1GABRG2GABRB3IRAK4NPC1 | |
| SCHEMBL15925373 | 0.78 | CHRNB2 (0.40) | OPRM1IRAK4NPC1MAPT | |
| SCHEMBL16910948 | 0.77 | NPC1 (0.37) | NPC1MAPT | |
| SCHEMBL27013408 | 0.76 | NOTUM (0.53) | NPC1MAPTNOTUM | |
| SCHEMBL21888960 | 0.75 | IRAK4 (0.36) | IRAK4NPC1MAPTNOTUMRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200115388-A1 | IRAK4 MODULATORS | GENENTECH, INC. (US) | 2020-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115388-A1 | IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | ELOVL1 2897/4885NR1H2 476/4885NR1H3 533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.