SCHEMBL21889554

SCHEMBL21889554

C[Si](C)(C)CCOCn1nc(C2CC2(F)F)nc1-c1ccc(OCc2ccccc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 3/20 0.45
ENPP3 O14638 1/20 0.39
ENPP1 P22413 1/20 0.39
MAOB P27338 4/20 0.36
PTGES O14684 1/20 0.35
MERTK Q12866 1/20 0.35
TP53 P04637 1/20 0.35
FDFT1 P37268 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21889199 0.87 DGAT1 (0.45) DGAT1ENPP3ENPP1MAOBPTGES
SCHEMBL21889298 0.85 DGAT1 (0.44) DGAT1ENPP3ENPP1MAOBPTGES
SCHEMBL21889821 0.85 DGAT1 (0.44) DGAT1ENPP3ENPP1MAOBPTGES
SCHEMBL21889844 0.85 DGAT1 (0.44) DGAT1ENPP3ENPP1MAOBPTGES
SCHEMBL21889556 0.84 DGAT1 (0.33) DGAT1MAOB
SCHEMBL21889837 0.83 AOC3 (0.46) DGAT1ENPP3ENPP1MAOBPTGES
SCHEMBL21914584 0.81 NPC1 (0.44) ENPP3ENPP1MAOBPTGESTP53
SCHEMBL16661083 0.80 DGAT1 (0.46) DGAT1ENPP3ENPP1MAOBPTGES
SCHEMBL21889223 0.80 DGAT1 (0.46) DGAT1ENPP3ENPP1MAOBPTGES
SCHEMBL21889304 0.79 DGAT1 (0.45) DGAT1ENPP3ENPP1MAOBPTGES

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210198220-A1 SSAO INHIBITOR SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2021-07-01 US disclosed
US-11001563-B2 SSAO inhibitor SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2021-05-11 US disclosed
US-20200115352-A1 SSAO INHIBITOR SHANDONG DANHONG PHARMACEUTICAL CO., LTD. 2020-04-16 US disclosed
EP-3626699-A1 SSAO INHIBITOR Shandong Danhong Pharmaceutical Co., Ltd. (CN) 2020-03-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11001563-B2 SSAO inhibitor SSB, ASAH2, AOX1 DGAT1 3115/4885ENPP3 497/4885ENPP1 462/4885
US-20210198220-A1 SSAO INHIBITOR SSB, ASAH2, AOX1 DGAT1 3115/4885ENPP3 497/4885ENPP1 462/4885
US-20200115352-A1 SSAO INHIBITOR SSB, ASAH2, AOX1 DGAT1 3115/4885ENPP3 497/4885ENPP1 462/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.