SCHEMBL21890179

SCHEMBL21890179

c1ccc(-n2c3ccccc3c3cc4c(cc32)c2cc3c(cc2n4-c2ccc(-c4ccc(-n5c6ccccc6c6cc7c(cc65)c5cc6c8cccnc8n8c9ccccc9nc8c6cc5n7-c5ccccc5)cc4)cc2)c2nc4ccccc4n2c2cccnc32)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.38
HPGD P15428 6/20 0.38
KMT2A Q03164 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
KDM4E B2RXH2 7/20 0.37
MAPT P10636 3/20 0.35
LMNA P02545 2/20 0.35
POLB P06746 2/20 0.35
HSD17B10 Q99714 2/20 0.35
TP53 P04637 1/20 0.35
ATM Q13315 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
TSHR P16473 1/20 0.34
CYP2C19 P33261 1/20 0.34
MEN1 O00255 1/20 0.33
PDE10A Q9Y233 4/20 0.32
TOP1 P11387 1/20 0.31
PDE4B Q07343 2/20 0.31
PDE4A P27815 1/20 0.30
PDE4C Q08493 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21298552 0.91 KDM4E (0.41) ALDH1A1HPGDKMT2ASMN1; SMN2KDM4E
SCHEMBL21298169 0.91 KDM4E (0.41) ALDH1A1HPGDKMT2ASMN1; SMN2KDM4E
SCHEMBL21890499 0.91 KDM4E (0.41) ALDH1A1HPGDKMT2ASMN1; SMN2KDM4E
SCHEMBL21890417 0.90 KDM4E (0.41) ALDH1A1HPGDKMT2ASMN1; SMN2KDM4E
SCHEMBL21890916 0.90 KDM4E (0.42) ALDH1A1HPGDKMT2ASMN1; SMN2KDM4E
SCHEMBL23948710 0.89 KDM4E (0.41) ALDH1A1HPGDKMT2ASMN1; SMN2KDM4E
SCHEMBL21890408 0.89 KDM4E (0.41) ALDH1A1HPGDKMT2ASMN1; SMN2KDM4E
SCHEMBL23948645 0.84 KDM4E (0.42) ALDH1A1HPGDKMT2AKDM4EMAPT
SCHEMBL23948700 0.84 KDM4E (0.42) ALDH1A1HPGDKMT2AKDM4EMAPT
SCHEMBL21890602 0.83 KDM4E (0.39) ALDH1A1HPGDKMT2ASMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10615349-B2 Donor-acceptor type thermally activated delayed fluorescent materials based on imidazo[1,2-F]phenanthridine and analogues ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2020-04-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10615349-B2 Donor-acceptor type thermally activated delayed fluorescent materials based on imidazo[1,2-F]phenanthridine and analogues SUN2, STAU1, HELZ ALDH1A1 558/4885HPGD 939/4885KMT2A 994/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.