Sugi Predict

Sugi Predict / Compounds / SCHEMBL2189055

SCHEMBL2189055

SCHEMBL2189055

CC(C)S(=O)(=O)N[C@H]1COCC[C@]1(O)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GRIA2 P42262 10/20 0.39
▸ KCNH2 Q12809 5/20 0.36
▸ GRIA4 P48058 3/20 0.36
▸ ALDH1A1 P00352 1/20 0.35
▸ CHRNA1 P02708 1/20 0.34
▸ CHRNG P07510 1/20 0.34
▸ CHRNB1 P11230 1/20 0.34
▸ CHRNB2 P17787 1/20 0.34
▸ SLC6A2 P23975 1/20 0.34
▸ CHRNB4 P30926 1/20 0.34
▸ CHRNA3 P32297 1/20 0.34
▸ CHRNA4 P43681 1/20 0.34
▸ CHRND Q07001 1/20 0.34
▸ MMP1 P03956 1/20 0.34
▸ MMP2 P08253 1/20 0.34
▸ MMP3 P08254 1/20 0.34
▸ MMP9 P14780 1/20 0.34
▸ MMP8 P22894 1/20 0.34
▸ MMP13 P45452 1/20 0.34
▸ MMP14 P50281 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2189254 1.00 GRIA2 (0.39) GRIA2KCNH2GRIA4ALDH1A1CHRNA1
SCHEMBL2190902 1.00 GRIA2 (0.39) GRIA2KCNH2GRIA4ALDH1A1CHRNA1
SCHEMBL2189970 1.00 GRIA2 (0.39) GRIA2KCNH2GRIA4ALDH1A1CHRNA1
SCHEMBL2191609 1.00 GRIA2 (0.39) GRIA2KCNH2GRIA4ALDH1A1CHRNA1
SCHEMBL2214676 0.88 GRIA2 (0.41) GRIA2KCNH2GRIA4CHRNA1CHRNG
SCHEMBL2217501 0.88 GRIA2 (0.41) GRIA2KCNH2GRIA4CHRNA1CHRNG
SCHEMBL2217503 0.88 GRIA2 (0.41) GRIA2KCNH2GRIA4CHRNA1CHRNG
SCHEMBL2217961 0.88 GRIA2 (0.41) GRIA2KCNH2GRIA4CHRNA1CHRNG
SCHEMBL12435031 0.88 GRIA2 (0.41) GRIA2KCNH2GRIA4CHRNA1CHRNG
SCHEMBL2214678 0.88 GRIA2 (0.41) GRIA2KCNH2GRIA4CHRNA1CHRNG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2361246-A1 OXOPIPERIDINYL AND PYRANYL SULFONAMIDES AS AMPA POTENTIATORS Pfizer Inc. (US) 2011-08-31 — — EP disclosed
US-20110172297-A1 Oxopiperdinyl And Pyranyl Sulfonamides and Pharmaceutical Compositions Thereof PFIZER INC 2011-07-14 — — US disclosed
US-20110172297-A1 Oxopiperdinyl And Pyranyl Sulfonamides and Pharmaceutical Compositions Thereof PFIZER INC 2011-07-14 — — US disclosed
WO-2010038167-A1 OXOPIPERIDINYL AND PYRANYL SULFONAMIDES AS AMPA POTENTIATORS PFIZER INC. (US) 2010-04-08 — — WO disclosed
WO-2010038167-A1 OXOPIPERIDINYL AND PYRANYL SULFONAMIDES AS AMPA POTENTIATORS PFIZER INC. (US) 2010-04-08 — — WO disclosed
US-20100035865-A1 Sulfonamides and Pharmaceutical Compositions Thereof PFIZER INC 2010-02-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100035865-A1 Sulfonamides and Pharmaceutical Compositions Thereof STS, SULT2A1, SULT1A1 GRIA2 3748/4885KCNH2 1167/4885GRIA4 3473/4885
US-20110172297-A1 Oxopiperdinyl And Pyranyl Sulfonamides and Pharmaceutical Compositions Thereof GRIK5, GABRE, GRIK2 GRIA2 34/4885KCNH2 577/4885GRIA4 25/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.