Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 6/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.50 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20325156 | 0.88 | CXCR4 (0.54) | CXCR4PRMT5WDR77NPC1SLC6A2 | |
| SCHEMBL15587410 | 0.84 | CXCR4 (0.65) | CXCR4PRMT5WDR77NPC1ACHE | |
| SCHEMBL11908903 | 0.82 | CXCR4 (0.53) | CXCR4PRMT5WDR77HTR2CMEN1 | |
| SCHEMBL13832686 | 0.82 | CXCR4 (0.53) | CXCR4PRMT5WDR77HTR2CMEN1 | |
| SCHEMBL20324416 | 0.82 | PRMT5 (0.46) | CXCR4PRMT5WDR77SLC6A2SLC6A4 | |
| SCHEMBL29889404 | 0.81 | EED (0.56) | SSTR4SLC6A2SLC6A4SLC6A3CHRM3 | |
| SCHEMBL1811542 | 0.81 | EED (0.56) | SSTR4SLC6A2SLC6A4SLC6A3CHRM3 | |
| SCHEMBL20324433 | 0.80 | PRMT5 (0.38) | CXCR4PRMT5WDR77SSTR4NPC1 | |
| SCHEMBL19314023 | 0.78 | EED (0.48) | CXCR4PRMT5WDR77HTR6KMT2A | |
| SCHEMBL20314219 | 0.78 | EP300 (0.44) | CXCR4PRMT5WDR77KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200115339-A1 | EFFLUX-PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | Basilea Pharmaceutica International AG (CH) | 2020-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115339-A1 | EFFLUX-PUMP INHIBITORS AND THERAPEUTIC USES THEREOF | ABCB11, ABCC1, ABCC3 | CXCR4 629/4885PRMT5 3801/4885WDR77 1607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.