Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 6/20 | 0.41 |
| ▸ | CDK9 | P50750 | 6/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.38 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL594143 | 0.76 | PRKCI (0.46) | CDK2CDK9CDK5CCNT1CCNA2 | |
| SCHEMBL23883560 | 0.76 | LRRK2 (0.59) | AURKACDK2CDK9CDK5CCNT1 | |
| SCHEMBL21620451 | 0.76 | HTR2A (0.46) | AURKACDK2LRRK2JAK2ROCK2 | |
| SCHEMBL31541397 | 0.76 | PRKCI (0.46) | CDK2CDK9CDK5CCNT1CCNA2 | |
| SCHEMBL14907823 | 0.76 | LOXL2 (0.47) | CDK2CDK9CDK5CCNT1CCNA2 | |
| SCHEMBL2881812 | 0.74 | ROCK2 (0.44) | AURKACDK2ROCK2ROCK1CDC42BPA | |
| SCHEMBL26349932 | 0.74 | AURKA (0.37) | AURKACDK2CDK9CDK5CCNT1 | |
| SCHEMBL4404315 | 0.72 | AURKA (0.37) | AURKACDK2JAK2ROCK2ROCK1 | |
| SCHEMBL30668767 | 0.72 | ROCK1 (0.57) | ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL22304206 | 0.72 | JAK2 (0.38) | CDK2CDK9CDK5CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020065613-A1 | MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-02 | — | — | WO | disclosed |