Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.35 |
| ▸ | PHGDH | O43175 | 2/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24225014 | 0.82 | ALDH1A1 (0.50) | LMNAALDH1A1HPGDMMP1MMP2 | |
| SCHEMBL15948654 | 0.79 | ALDH1A1 (0.57) | LMNAALDH1A1HPGDMMP1MMP2 | |
| SCHEMBL2327551 | 0.79 | LMNA (0.78) | LMNAALDH1A1HPGDMMP1MMP2 | |
| SCHEMBL20220309 | 0.77 | LMNA (0.60) | LMNAALDH1A1HPGDMMP1MMP2 | |
| SCHEMBL3897633 | 0.75 | LMNA (0.64) | LMNAALDH1A1HPGDMMP1MMP2 | |
| SCHEMBL13461838 | 0.75 | LMNA (0.50) | LMNAALDH1A1HPGDMMP1MMP2 | |
| SCHEMBL7134945 | 0.75 | — | — | |
| SCHEMBL18735214 | 0.74 | LMNA (0.50) | LMNAALDH1A1HPGDMMP1MMP2 | |
| SCHEMBL3306771 | 0.74 | LMNA (0.89) | LMNAALDH1A1HPGDMMP1MMP2 | |
| SCHEMBL633287 | 0.74 | LMNA (0.70) | LMNAALDH1A1HPGDMMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3943087-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | Celgene CAR LLC (BM) | 2022-01-26 | — | — | EP | disclosed |
| EP-2953457-B1 | ERK INHIBITORS AND USES THEREOF | CELGENE CAR LLC (BM) | 2020-04-08 | — | — | EP | disclosed |