Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | PIR | O00625 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24783883 | 0.93 | MAP4K1 (0.36) | BTKPIRPIK3CDMAP4K1RAPGEF4 | |
| SCHEMBL10094593 | 0.84 | SYK (0.40) | PIK3CDMAP4K1RAPGEF4NPC1RAB9A | |
| SCHEMBL30476640 | 0.78 | RAPGEF4 (0.44) | RAPGEF4NPC1RAB9APOLBHTT | |
| SCHEMBL13990429 | 0.78 | RAPGEF4 (0.44) | RAPGEF4NPC1RAB9APOLBHTT | |
| SCHEMBL6292391 | 0.76 | PIR (0.47) | PIRMAPK1NPC1RAB9APOLB | |
| SCHEMBL28411207 | 0.75 | MAPT (0.43) | NPC1RAB9APOLBHPGDHTT | |
| SCHEMBL13606983 | 0.75 | SMN1; SMN2 (0.40) | ALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL8237889 | 0.75 | PIK3CD (0.36) | BTKPIRPIK3CDRAB9APOLB | |
| SCHEMBL4546338 | 0.74 | RAPGEF4 (0.55) | RAPGEF4NPC1RAB9APOLBHPGD | |
| SCHEMBL12385887 | 0.74 | RAPGEF4 (0.50) | RAPGEF4NPC1RAB9APOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020065613-A1 | MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-02 | — | — | WO | disclosed |