Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22994735 | 0.75 | KRAS (0.51) | KRASHSP90AA1HSP90B1 | |
| SCHEMBL22994858 | 0.69 | TRPV1 (0.40) | KRASTRPV1P2RX3P2RX2 | |
| SCHEMBL21846371 | 0.68 | KRAS (0.40) | KRAS | |
| SCHEMBL21895551 | 0.67 | KRAS (0.33) | KRAS | |
| SCHEMBL25020057 | 0.65 | KRAS (0.41) | KRAS | |
| SCHEMBL22994738 | 0.65 | KRAS (0.60) | KRASHSP90AA1HSP90B1 | |
| SCHEMBL19637392 | 0.65 | MEN1 (0.40) | HSP90AA1HSP90B1 | |
| SCHEMBL22994794 | 0.64 | KRAS (0.59) | KRAS | |
| SCHEMBL21895737 | 0.62 | KRAS (0.52) | KRASHSP90AA1HSP90B1 | |
| SCHEMBL21846369 | 0.61 | KRAS (0.52) | KRASHSP90AA1HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020055756-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |