Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21912138 | 0.89 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL22086716 | 0.87 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL25019973 | 0.83 | — | — | |
| SCHEMBL21912065 | 0.80 | KDM4E (0.34) | — | |
| SCHEMBL19637446 | 0.78 | KDM4E (0.36) | — | |
| SCHEMBL22994752 | 0.76 | KDM4E (0.35) | — | |
| SCHEMBL22994768 | 0.76 | KDM4E (0.32) | — | |
| SCHEMBL19636821 | 0.76 | KDM4E (0.37) | — | |
| SCHEMBL22994676 | 0.73 | KDM4E (0.34) | — | |
| SCHEMBL25021516 | 0.69 | KRAS (0.39) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710439-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2023-02-15 | — | — | EP | disclosed |
| WO-2020055756-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |
| WO-2020055755-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |