Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NMT2 | O60551 | 2/20 | 0.31 |
| ▸ | NMT1 | P30419 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19636821 | 0.85 | KDM4E (0.37) | KDM4EMAPTHPGDNPSR1MEN1 | |
| SCHEMBL21912065 | 0.84 | KDM4E (0.34) | KDM4EMAPTHPGDNPSR1MEN1 | |
| SCHEMBL19637446 | 0.82 | KDM4E (0.36) | KDM4EMAPTHPGDNPSR1MEN1 | |
| SCHEMBL22994752 | 0.81 | KDM4E (0.35) | KDM4EMAPTHPGDNPSR1MEN1 | |
| SCHEMBL22994768 | 0.81 | KDM4E (0.32) | KDM4EMAPTHPGDNPSR1MEN1 | |
| SCHEMBL21896269 | 0.73 | CHRNB2 (0.36) | — | |
| SCHEMBL25019973 | 0.71 | — | — | |
| SCHEMBL25020961 | 0.70 | KDM4E (0.34) | KDM4EMAPTHPGDNPSR1MEN1 | |
| SCHEMBL22087278 | 0.69 | — | — | |
| SCHEMBL19637369 | 0.67 | HTT (0.35) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458445-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2021-02-17 | — | — | EP | disclosed |