Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.46 |
| ▸ | GABRE | P78334 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.46 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.46 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.46 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20230878 | 0.84 | — | — | |
| SCHEMBL18885332 | 0.78 | HDAC8 (0.54) | TSHRALDH1A1SMN1; SMN2EPHX1MEN1 | |
| SCHEMBL5326 | 0.76 | POLB (0.54) | POLBGABRPGABRDGABRA1TSHR | |
| Hydrochloric Acid SCHEMBL4788809 | 0.74 | POLB (0.52) | POLBGABRPGABRDGABRA1TSHR | |
| SCHEMBL4693634 | 0.73 | HDAC8 (0.58) | POLBGABRPGABRDGABRA1TSHR | |
| SCHEMBL5808330 | 0.73 | POLB (0.61) | POLBGABRPGABRDGABRA1TSHR | |
| SCHEMBL2727964 | 0.72 | POLB (0.50) | POLBGABRPGABRDGABRA1TSHR | |
| SCHEMBL1018964 | 0.72 | GNAI3 (0.64) | POLBGABRPGABRDGABRA1TSHR | |
| SCHEMBL3224577 | 0.72 | POLB (0.50) | POLBGABRPGABRDGABRA1TSHR | |
| Hydrochloric Acid SCHEMBL31229116 | 0.71 | HDAC8 (0.56) | POLBGABRPGABRDGABRA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478680-B1 | NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HBV INFECTION | HOFFMANN LA ROCHE (CH) | 2020-04-22 | — | — | EP | disclosed |