SCHEMBL2189977

SCHEMBL2189977

C=C(C)COCC(O)CO[Si](CCC)(O[Si](C)(C)C)O[Si](C)(C)C

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3627739 0.79
SCHEMBL2189982 0.78 TSHR (0.41)
SCHEMBL201963 0.74 KDM4E (0.34)
SCHEMBL347663 0.72 KDM4E (0.38)
SCHEMBL35464 0.71
SCHEMBL396760 0.70
SCHEMBL7049601 0.70 TSHR (0.37)
SCHEMBL4895728 0.70
SCHEMBL9301559 0.69
SCHEMBL396531 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2342588-B9 IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY JOHNSON & JOHNSON VISION CARE (US) 2024-10-02 EP disclosed
EP-2342588-B1 IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY JOHNSON & JOHNSON VISION CARE (US) 2024-07-03 EP disclosed
US-9851472-B2 Silicone-based hydrophilic copolymer and hydrogel compositions comprising the same MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2017-12-26 US disclosed
US-20160282517-A1 SILICONE-BASED HYDROPHILIC COPOLYMER AND HYDROGEL COMPOSITIONS COMPRISING THE SAME MOMENTIVE PERFORMANCE MATERIALS INC. 2016-09-29 US disclosed
US-9260544-B2 Ionic silicone hydrogels having improved hydrolytic stability JOHNSON & JOHNSON VISION CARE, INC. (US) 2016-02-16 US disclosed
US-9101667-B2 Ionic silicone hydrogels comprising pharmaceutical and/or neuticeutical components and having improved hydrolytic stability JOHNSON & JOHNSON VISION CARE, INC. (US) 2015-08-11 US disclosed
US-20140329859-A1 IONIC SILICONE HYDROGELS COMPRISING PHARMACEUTICAL AND/OR NEUTICEUTICAL COMPONENTS AND HAVING IMPROVED HYDROLYTIC STABILITY JOHNSON & JOHNSON VISION CARE (US) 2014-11-06 US disclosed
US-20140296440-A1 IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY JOHNSON & JOHNSON VISION CARE (US) 2014-10-02 US disclosed
US-8815972-B2 Ionic silicone hydrogels having improved hydrolytic stability JOHNSON & JOHNSON VISION CARE, INC. (US) 2014-08-26 US disclosed
US-20130261215-A1 IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY JOHNSON & JOHNSON VISION CARE, INC. (US) 2013-10-03 US disclosed
US-20130203812-A1 IONIC SILICONE HYDROGELS COMPRISING PHARMACEUTICAL AND/OR NUTRICEUTICAL COMPONENTS AND HAVING IMPROVED HYDROLYTIC STABILITY JOHNSON & JOHNSON VISION CARE, INC. (US) 2013-08-08 US disclosed
US-8470906-B2 Ionic silicone hydrogels having improved hydrolytic stability JOHNSON & JOHNSON VISION CARE, INC. (US) 2013-06-25 US disclosed
EP-2342588-A1 IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY Johnson & Johnson Vision Care, Inc. (US) 2011-07-13 EP disclosed
US-20100249356-A1 IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY JOHNSON & JOHNSON VISION CARE, INC. 2010-09-30 US disclosed
WO-2010039653-A1 IONIC SILICONE HYDROGELS HAVING IMPROVED HYDROLYTIC STABILITY JOHNSON & JOHNSON VISION CARE, INC. (US) 2010-04-08 WO disclosed