Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 6/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.53 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.53 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.53 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.53 |
| ▸ | CACNG8 | Q8WXS5 | 5/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18190765 | 0.81 | GRIA1 (0.57) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL18190720 | 0.79 | GRIA1 (0.55) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL12322303 | 0.79 | GRIA1 (0.58) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL10139187 | 0.79 | PTK6 (0.49) | GRIA1CACNG8PDE3BPDE3AKMT2A | |
| SCHEMBL18190461 | 0.76 | GRIA1 (0.68) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL21900280 | 0.75 | GRIA1 (0.84) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL18190759 | 0.75 | GRIA1 (0.50) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL26463261 | 0.75 | PDE3B (0.59) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL13306916 | 0.74 | GRIA1 (0.53) | GRIA1GRIK1GRIA2GRIA3GRIA4 | |
| SCHEMBL18190480 | 0.72 | GRIA1 (0.62) | GRIA1GRIK1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144730-A1 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHAMACEUTICALS (US) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144730-A1 | PYRIDINONYL PDK1 INHIBITORS | PDK1, PDK2, PDK3 | GRIA1 2618/4885GRIK1 1764/4885GRIA2 2949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.