Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | AGXT | P21549 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22266190 | 0.83 | TSHR (0.48) | PARP10RAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL13870217 | 0.81 | L3MBTL1 (0.58) | PARP10RAB9ANPC1AGXTCA2 | |
| SCHEMBL20314597 | 0.81 | POLB (0.49) | PARP10RAB9ANPC1AGXTMAPT | |
| SCHEMBL12270447 | 0.80 | AGXT (0.58) | RAB9ANPC1AGXTCA2CA1 | |
| SCHEMBL8802965 | 0.79 | CYP2C9 (0.49) | RAB9ANPC1AGXTCA2CA1 | |
| SCHEMBL906396 | 0.79 | TSHR (0.52) | PARP10RAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL21664684 | 0.79 | RAB9A (0.54) | PARP10RAB9ANPC1AGXTCA2 | |
| SCHEMBL16682541 | 0.77 | AGXT (0.47) | RAB9ANPC1AGXTCA2CA1 | |
| SCHEMBL16449107 | 0.77 | AGXT (0.47) | RAB9ANPC1AGXTCA2CA1 | |
| SCHEMBL16682540 | 0.77 | AGXT (0.52) | PARP10RAB9ANPC1AGXTCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200121684-A1 | MODULATORS OF BTK PROTEOLYSIS AND METHODS OF USE | UNIV YALE (US) | 2020-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200121684-A1 | MODULATORS OF BTK PROTEOLYSIS AND METHODS OF USE | BTK, CBL, CRBN | PARP10 2047/4885RAB9A 3451/4885NPC1 3757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.