Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | DGKA | P23743 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17286168 | 1.00 | ALDH1A1 (0.47) | ALDH1A1TRPA1CES2CYP1A2GAA | |
| SCHEMBL9773565 | 1.00 | ALDH1A1 (0.47) | ALDH1A1TRPA1CES2CYP1A2GAA | |
| SCHEMBL22906936 | 1.00 | ALDH1A1 (0.47) | ALDH1A1TRPA1CES2CYP1A2GAA | |
| SCHEMBL6137569 | 1.00 | ALDH1A1 (0.47) | ALDH1A1TRPA1CES2CYP1A2GAA | |
| SCHEMBL5219102 | 0.98 | ALDH1A1 (0.48) | ALDH1A1TRPA1CES2CYP1A2GAA | |
| SCHEMBL16147050 | 0.92 | ALDH1A1 (0.50) | ALDH1A1TRPA1CES2CYP1A2GAA | |
| SCHEMBL21070768 | 0.90 | CES2 (0.52) | ALDH1A1TRPA1CES2CYP1A2GAA | |
| SCHEMBL8988864 | 0.88 | CES2 (0.50) | ALDH1A1TRPA1CES2CYP1A2GAA | |
| SCHEMBL23720522 | 0.87 | ALDH1A1 (0.45) | ALDH1A1TRPA1CES2CYP1A2GAA | |
| SCHEMBL24882784 | 0.86 | GAA (0.48) | ALDH1A1TRPA1CES2CYP1A2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210380579-A1 | PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND /OR SMARCA4 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-12-09 | — | — | US | disclosed |
| WO-2020078933-A1 | PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND/OR SMARCA4 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210380579-A1 | PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND /OR SMARCA4 | SMARCC1, SMARCA4, SMARCA1 | ALDH1A1 2957/4885TRPA1 4522/4885CES2 2326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.