Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21901753 | 0.82 | ALDH1A1 (0.66) | SMN1; SMN2KDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL16761948 | 0.82 | KDM4E (0.66) | SMN1; SMN2KDM4EALDH1A1LMNANPSR1 | |
| SCHEMBL2834496 | 0.81 | ALDH1A1 (0.59) | SMN1; SMN2KDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL6142793 | 0.79 | ALDH1A1 (0.71) | SMN1; SMN2KDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL30703390 | 0.79 | ALDH1A1 (0.71) | SMN1; SMN2KDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL2267829 | 0.77 | HSD17B10 (0.73) | SMN1; SMN2KDM4EALDH1A1LMNANPSR1 | |
| SCHEMBL22404982 | 0.76 | NPSR1 (0.57) | SMN1; SMN2LMNANPSR1MEN1KMT2A | |
| SCHEMBL6509007 | 0.76 | NPSR1 (0.57) | SMN1; SMN2KDM4EALDH1A1NPSR1MEN1 | |
| SCHEMBL21901796 | 0.74 | GRIN2B (0.44) | ALDH1A1MEN1KMT2AGAAPOLB | |
| SCHEMBL4598308 | 0.74 | ALDH1A1 (0.58) | SMN1; SMN2KDM4EALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3867245-B1 | 4-PYRIMIDIN-5-YLMETHYL-MORPHOLINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM INT (DE) | 2022-12-07 | — | — | EP | disclosed |
| US-20200123140-A1 | 4-Pyrimidin-5-ylmethyl-morpholine derivatives and the use thereof as medicament | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2020-04-23 | — | — | US | disclosed |
| WO-2020079040-A1 | 4-PYRIMIDIN-5-YLMETHYL-MORPHOLINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123140-A1 | 4-Pyrimidin-5-ylmethyl-morpholine derivatives and the use thereof as medicament | GRIN2C, GRIN2A, GRIN3A | SMN1; SMN2 1214/4885KDM4E 507/4885ALDH1A1 901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.